Impact of Hyaluronidase (ALT-B4) on Pharmacokinetics & Local Tolerability in Subcutaneous ADC Administration

• Outlining pharmacokinetic changes associated with IV-to- SC route conversion of ADCs: comparative analysis and mathematical modeling of ADC and payload disposition
• Exploring the role of hyaluronidase (ALT-B4) in modulating local tolerability and injection-site reactions following subcutaneous ADC administration
• Discussing key considerations and strategic approaches for successful subcutaneous ADC formulation development using hyaluronidase co-administration

Speakers:

Tae Hwan Kim

Associate Professor, College of Pharmacy

Daegu Catholic University